Organic Acids
Cayman Chemical PamoIc AcId 250g
A potent agonist of GPR35 orphan receptors (EC50 = 79 nM in a β-arrestin recruitment assay); induces GPR35 translocation from the plasma membrane to the cytoplasm (EC50 =22 nM); increases ERK1/2 phosphorylation in a concentration-dependent manner in U20S cells expressing human GPR35a; has antinociceptive effects in a mouse abdominal constriction model of visceral pain perception (ED50 = 40.5 mg/kg)
Medchemexpress LLC Pamoic acid | 130-85-8 | 99.69% | 388.38 | 5 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective properties.
- Exhibits anti-inflammatory properties.
Medchemexpress LLC Pamoic acid | 130-85-8 | 99.7% | 388.38 | 25 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties.
- Potent GPR35 agonist (EC50 of 79 nM).
- Exhibits neuroprotective properties.
- Exhibits anti-inflammatory properties.
- Reduces infarct size in a mouse model of stroke.
- Increases noninflammatory Ly-6CLo monocytes/macrophages and reduces neutrophil counts in the ischemic brain.
- GPR35 activation may increase ERK1/2 phosphorylation, initiating an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.
Medchemexpress LLC Pamoic acid (disodium) | 6640-22-8 | 99.9% | 432.34 | 25 G
Pamoic acid (disodium) | 6640-22-8 | 99.9% | 432.34 | 25 G
Medchemexpress LLC Pamoic acid (Embonic acid) | 130-85-8 | 99.7% | 388.38 | 100 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist that demonstrates neuroprotective and anti-inflammatory properties. Its GPR35 activation may increase the phosphorylation of ERK1/2, which helps to suppress NF-κB-dependent inflammatory genes.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Shows agonist activity at human GPR35 in CHO cell lines.
- Demonstrates neuroprotective activity in a mouse stroke model.
- Reduces infarct size in a GPR35-dependent manner.
- Increases noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain.
- Reduces neutrophil counts.
Medchemexpress LLC Pamoic acid | 130-85-8 | 99.7% | 388.38 | 10 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective and anti-inflammatory properties.
- Activates GPR35, which may increase the phosphorylation of ERK1/2, initiating an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes.
- Has neuroprotective activity in a mouse model of stroke, reducing infarct size in a GPR35 dependent manner.
- Pamoic acid treatment results in a preferential increment of noninflammatory Ly-6CLo monocytes/macrophages in the ischemic brain along with reduced neutrophil counts.
Medchemexpress LLC Pamoic acid | 130-85-8 | 99.7% | 388.38 | 50 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties, making it suitable for research into neurological and inflammatory diseases.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective and anti-inflammatory properties.
- GPR35 activation may increase phosphorylation of ERK1/2, suppressing NF-κB-dependent inflammatory genes.
- Shows neuroprotective activity by activating GPR35, reducing infarct size in mouse stroke models.
- Increases noninflammatory Ly-6CLo monocytes/macrophages and reduces neutrophil counts in the ischemic brain.
Cayman Chemical R Mandelic Acid Pharmaceutical
A synthetic intermediate useful for pharmaceutical synthesis.
Cayman Chemical R Mandelic Acid Pharmaceutical
A synthetic intermediate useful for pharmaceutical synthesis.
Medchemexpress LLC Mandelic acid | 90-64-2 | MFCD00064250 | 99.9% | 152.15 g/mol | C8H8O3 | 50 G
Mandelic acid (CAS 90-64-2) is an alpha-hydroxycarboxylic acid used as a research reagent and synthetic intermediate in pharmaceutical and fine-chemical applications. It shows antimicrobial activity and is supplied with batch-specific quality documentation for analytical and formulation work.
- High purity (99.92% assay by HPLC).
- White crystalline solid, suitable for analytical use.
- Commonly used as a synthetic intermediate and research reagent.
- Soluble in polar organic solvents, facilitating formulations.
- Provided with batch-specific certificate of analysis for QC.
Cayman Chemical R Mandelic Acid Pharmaceutical
A synthetic intermediate useful for pharmaceutical synthesis.